RNA Details
Disease Name
Radiation Pneumonitis
Tissue
lung
RNA Symbol
mir-34a
RNA ID
RNA Type
miRNA
Alteration Pattern
dysregulation
Species
mus musculus
Detection Methods
Quantstudio openarray profiling; X-ray radiation treatment; qRT-PCR etc.
Target
NA
Pathway
NA
PubMed ID
Title
Dietary flaxseed modulates the miRNA profile in irradiated and non-irradiated murine lungs: a novel mechanism of tissue radioprotection by flaxseed
Year
2014
Function
"Dietary flaxseed (FS) significantly modulated expression of multiple miRNAs, including 7 with P<0.001. MiR-150 was downregulated in the FS groups and is disproportionately integrated into immune response-related networks. Although few miRNAs were significantly changed by radiation, interaction between diet and radiation was observed. For example, miR-29c was greatly downregulated in the FS/Control group (10- to 50-fold) but slightly upregulated in the FS/radiation group. Compared with FS/control, the FS/radiation group experienced a 50% decrease of the p53-responsive miR-34a, which regulates senescence- and apoptosis-related factors. FS induced significant changes in lung miRNA profile suggesting that modulation of small RNA by dietary supplements may represent a novel strategy to prevent adverse side-effects of thoracic radiotherapy."